Zoloft - antidepressant, a specific inhibitor of serotonin reuptake. It is used to treat and prevent depression of various etiologies, obsessive-compulsive disorder, panic disorder, social phobia, posttraumatic stress disorder.
Latin name:
Zoloft / ZOLOFT.
The composition and the form of:
Zoloft tablets, coated on 14 or 28 pieces. in the package.
1 tablet contains Zoloft: sertraline hydrochloride 50 or 100 mg.
Properties / Action:
buy Zoloft - antidepressant, a specific inhibitor of serotonin reuptake. buy Zoloft antidepressant effect develops within 2-4 weeks of admission.
buy Zoloft has no affinity for muscarinic, serotonin, dopamine, histamine, GABA, benzodiazepine and adrenoceptors. It has no stimulating, sedative or anticholinergic action, not cause drug addiction, does not cause increase in body weight during chronic administration.
Indications:
depression of various etiologies, prevention of recurrence of depression;
obsessive-compulsive disorder;
panic disorder (with or without agoraphobia);
social phobia;
Post-traumatic Stress disorder.
Dosage and administration:
buy Zoloft appointed interior, 1 time per day, regardless of the meal.
Depression and obsessive-compulsive disorder. buy Zoloft is prescribed in the initial dose of 50 mg / day. In the absence of the effect of the dose can be increased to 50 mg 1 every 1-2 weeks. The maximum daily dose of buy Zoloft to 200 mg.
Panic disorder, Post Traumatic Stress disorder and social phobia. buy Zoloft is prescribed in the initial dose of 25 mg / day, which increased after 1 week to 50 mg / day (reduces the incidence of early adverse effects of treatment, specific to panic disorder). When little effect dose of buy Zoloft can increase to 50 mg per day at intervals of 1-2 weeks. The maximum daily dose - 200 mg.
Clinical effect of buy Zoloft may occur already after 7 days after starting treatment, but the full effect is usually achieved within 2-4 weeks or for a longer time (eg, obsessive-compulsive disorder).
When conducting long-term maintenance treatment of buy Zoloft is prescribed in the lowest effective dose, which subsequently change depending on the clinical effectiveness.
Children. In children aged 6-12 years treated with a starting dose of buy Zoloft 25 mg per day. After 1 week increase the dose to 50 mg per day. When little effect dose can be increased to 50 mg every 1-2 weeks to the maximum - 200 mg / day. Increasing the daily dose of buy Zoloft more than 50 mg should be taken into account the smaller body weight in children compared with adults, to avoid overdose.
Elderly patients. buy Zoloft prescribed the same dose as younger patients.
Violations of liver function. buy Zoloft should be used in smaller doses or increase the interval between doses.
Renal function. Adjustment buy Zoloft dosing regime is not required.
Overdose: Severe symptoms of overdose of buy Zoloft is not revealed. With the introduction of buy Zoloft in combination with other drugs or alcohol may be confronted with serious poisoning (known fatal cases).
Treatment: ingestion of activated charcoal (induce vomiting is not recommended); require intensive supportive therapy and continuous monitoring of vital functions of the organism. No specific antidote. Increased diuresis or dialysis may be ineffective.
Contraindications:
idiosyncrasy (including a history of hypersensitivity) components buy Zoloft;
simultaneous appointment of MAO inhibitors and pimozide;
Children under 6 years;
pregnancy and breastfeeding (controlled by the results of not).
Side effects:
On the part of the organism as a whole: increased sweating, changes in body weight, weakness.
From the nervous system: dizziness, insomnia or drowsiness, tremor, headache, anxiety, agitation, hypomania, mania, gait disturbance, visual disturbances, extrapyramidal disorders (dyskinesia, akathisia), paresthesias, seizures. Upon the termination of treatment buy Zoloft described rare cases of withdrawal (may appear paresthesia, gipostezii, symptoms of depression, hallucinations, aggressive reaction, psychomotor agitation, anxiety or psychotic symptoms that are indistinguishable from the symptoms of the underlying disease).
Since the cardiovascular system: hot flushes, palpitations, bleeding.
From the digestive system: dry mouth, dyspepsia, nausea, vomiting, diarrhea, decreased or increased appetite, anorexia, abdominal pain, increase in liver transaminases in serum.
On the part of the endocrine and genital systems: menstrual irregularities, galactorrhoea, hyperprolactinaemia, violation of sexual function in men (a decrease of potency, delayed ejaculation).
Allergic and Dermatological reactions: skin itching, rash, Stevens-Johnson syndrome, epidermal necrolysis.
From the laboratory parameters: transient hyponatremia.
Cautions and precautions:
From the beginning of treatment and buy Zoloft to achieve remission of the disease for the sick should establish a permanent medical surveillance. Patients with depression are at risk for suicide attempts, and this risk persists until the development of remission.
Motor disturbances frequently observed in patients with indications of their presence in history or concomitant use of antipsychotics.
Hypomania or mania may develop in about 0.4% of patients receiving buy Zoloft. Cases of activation of mania or hypomania have also been described in a small number of patients with manic-depressive psychosis, receiving other antidepressant drugs or antiobsessivnye.
Between the abolition of buy Zoloft and the appointment of MAO inhibitors should get at least 2 weeks, with the abolition of the MAO inhibitors buy Zoloft can be given not earlier than 2 weeks. Precautions should be used with drugs buy Zoloft, depressing the central nervous system. The combined use of buy Zoloft to lithium is recommended to control the level of lithium in blood plasma. Joint appointment buy Zoloft with other drugs that increase serotonergic neurotransmission (tryptophan, fenfluramine, 5-HT-agonists) on the possibility should be excluded. Need to be cautious when moving from receiving other antidepressant and antiobsessivnyh means for receiving buy Zoloft (especially with long-acting means, eg, fluoxetine). Alcohol drinking (including preparations containing ethanol) during therapy buy Zoloft is prohibited.
Should avoid the use of buy Zoloft in patients with unstable epilepsy (no experience with). Patients with controlled epilepsy should be carefully observed during treatment. When seizures buy Zoloft should be abolished.
Patients with hepatic impairment should be treated with lower doses of buy Zoloft.
Women of reproductive age during treatment with buy Zoloft should use effective methods of contraception.
During the application of buy Zoloft is not recommended to drive vehicles, special equipment or engage in activities associated with an increased risk.
Drug Interactions:
Simultaneous treatment with buy Zoloft and pimozide is contraindicated (increase in serum levels of pimozide).
Simultaneous treatment with MAO inhibitors (including selegiline and moclobemide) and buy Zoloft is contraindicated (leading to the development of serotonin syndrome: nausea, vomiting, drowsiness, tachycardia, agitation, dizziness, psychomotor agitation, diarrhea, sweating, myoclonus, hyperreflexia, possible heavy complications).
buy Zoloft is not compatible with serotonergic means, avoiding the joint appointment of tryptophan or fenfluramine.
Sertraline is associated plasma protein (necessary to consider the possibility of interaction buy Zoloft with diazepam, tolbutamide, warfarin, cimetidine).
Simultaneous administration of warfarin resulted in a slight increase in prothrombin time (it is recommended to monitor the prothrombin time in the beginning of treatment buy Zoloft and after its cancellation).
At the same time.The buy Zoloft decreases tolbutamide clearance (requires monitoring of blood glucose levels).
Concomitant use of buy Zoloft to cimetidine significantly reduces the clearance of sertraline.
In a joint appointment buy Zoloft phenytoin is recommended to carefully monitor the level of phenytoin in the blood plasma (if necessary - dosage adjustment of phenytoin).
The combined use of buy Zoloft with lithium leads to an increase in the frequency of side effects, often observed tremor (requires increased caution and monitor lithium levels in blood plasma).
Long-term treatment buy Zoloft at 50 mg / day increases the plasma concentrations simultaneously used drugs in the metabolism of which involved isoenzyme CYP2D6 (tricyclic antidepressants, propafenone, flekainid).
In a joint appointment with buy Zoloft sumatriptanom possible rare cases of weakness, increased tendon reflexes, confusion, anxiety and excitement (recommended monitoring patients).
